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Can woman get pregnant with bone marrow

Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy. In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium.

SEE VIDEO BY TOPIC: Bone Marrow Transplant - Mayo Clinic

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By Roxanne Khamsi. In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm.

But experts caution that provoking the sperm precursors to fully mature presents a serious challenge. In July , biologist Karim Nayernia at the University of Newcastle-upon-Tyne in the UK, and colleagues reported they had successfully converted stem cells from mouse embryos into functioning sperm that could fertilise mouse eggs and produce live offspring. The researchers mixed these cells with proteins that promote cell growth and vitamin A, which appears to play an important role in sperm development.

This mixture converted the cells into sperm stem cells, called spermatogonium cells. Sperm stem cells are normally found in the testes, where they divide to help provide a continuous supply of sperm see diagram, right. While sperm stem cells have two sets of chromosomes, mature sperm capable of fertilising eggs have only one set.

Nayernia says his ongoing experiments have suggested that sperm cells derived from the bone stem cells of mice can undergo the first two of three divisions necessary to become mature sperm.

He says that his team will work to achieve all the necessary divisions in mice before trying similar manipulations with human cells. Experts caution that turning sperm stem cells derived from bone marrow into functioning sperm would be no small feat. Stem cell biologist Harry Moore at the University of Sheffield in the UK worries that sperm created from bone stem cells could have undetectable abnormalities that could cause disease in offspring.

Nevertheless, Nayernia remains optimistic about manipulating stem cells to treat infertility, and says a positive outcome could help many men, including those whose sperm stem cells have been destroyed by potent anti-cancer drugs.

Nayernia hopes that one day it might be possible to inject the sperm stem cells directly into the testes of human patients, so that these men can conceive naturally as opposed to using IVF. And women may be able to use the technique to produce sperm, allowing lesbian couples to have their own biological daughters.

Nayernia says that researchers have produced the same early-stage sperm cells in mice from bone marrow cells taken from female mice. By Roxanne Khamsi Sperm stem cells are normally found in the testes, where they divide to help provide a continuous supply of sperm.

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Female sperm

I guess after being told to "Go Fuck Yourself" for so many years, these scientists finally found a way to do it. There will be some interesting debates raging about this one for a long time. I'm of the opinion that on the whole, we are better off with the process of gene mixing than practicing self-eugenics. Since when is human reproduction about strengthening the gene pool, and since when are your "gay friends" inherently unable to reproduce naturally? Better question is "since when is natural a good thing"?

Log in Advanced Search. A study in mice suggests that bone marrow-derived stem cells may play a role in establishing pregnancy.

By Roxanne Khamsi. In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells. If these precursor cells can be coaxed into becoming fully functioning sperm cells, the technique could allow infertile men to father their own children, and even allow women to produce their own sperm. But experts caution that provoking the sperm precursors to fully mature presents a serious challenge.

Bone marrow stem cells may be vital for pregnancy

Stem cells have generated such an enormous amount of interest, in part, because of their applications related to areas such as fertility and genetics. In that same light, their interest for solving reproductive challenges has also generated a great deal of controversy. This is particularly true in the application of stem cells to facilitate reproduction for gay couples. At present, there are a number of research laboratories that are focused on the creation of cells that are genetically male but have been produced from eggs. Alternately, they are also trying to create sperm from female eggs. If the research proves to work, the consequences are particularly important for gay and lesbian couples that wish to have children. The idea is, however, an extremely controversial one that mixes in with politics, religion and ethics. Many individuals oppose same-sex reproduction while gay and lesbian couples - as well as heterosexual members of the public - argue that gay persons should have the right to produce and raise biological children if the opportunity becomes available. Current Research for Same Sex Reproduction The techniques purported to allow same-sex reproduction have yet to be successful but they do hold promise. They include methods of cellular reprogramming and even techniques such as artificial chromosomes.

Stem Cells and Same Sex Reproduction

The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

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But recently a team of scientists announced they had made artificial sperm from human bone marrow , and media reports abounded with the dire news that my goodfellas and by extension, me had been rendered unnecessary. There are at least half a dozen reasons why such speculation is silly, some scientific and some practical. For example, as long as sex feels good and remains no more expensive than dinner and a bottle of wine, most people will use natural-grown sperm.

Bone marrow may be the missing piece of the fertility puzzle

Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner.

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Bone stem cells turned into primitive sperm cells

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METHODS AND RESULTS: Autologous embryos from in vitro-fertilized ova were successfully implanted in a year-old woman, 2 years after successful  by JH Lipton - ‎ - ‎Cited by 24 - ‎Related articles.

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